Research present promise in cardiovascular well being and diabetes

In a latest evaluate revealed in VitaminsThe researchers reviewed current information on the organic results of pomegranates (Punica granatum LPG) Polyphenols on metabolic issues.

Study: The biological effects of pomegranate (Punica granatum L.) polyphenols on metabolic disorders: understanding their protective role against metabolic syndrome.  Image source: azeraijan_stockers/
Examine: The organic results of pomegranate (Punica granatum L.) polyphenols on metabolic issues: understanding their protecting position towards metabolic syndrome. Picture supply: azeraijan_stockers/


Pomegranate, a pure nutrient, has lengthy been used to deal with bacterial infections, diabetes, weight problems and different metabolic issues. Nonetheless, considerations have been expressed about unintended effects of drug therapies resembling anti-obesity and insulin-sensitizing drugs. Latest analysis helps the health-promoting advantages of polyphenol-rich pure merchandise and diets, together with antibacterial, anti-diabetic, anti-obesity, and atherosclerosis-protective properties.

In regards to the evaluate

Within the present evaluate, researchers examined the pharmacokinetic properties, security, and bioavailability of PG compounds within the prevention of metabolic issues resembling kind 2 diabetes, weight problems, dyslipidemia, and cardiovascular-related illnesses.

Prevention of metabolic issues by consuming PG

PG is a plant that may scale back insulin resistance, cytokine ranges, redox gene expression, elevated blood strain, vascular harm, and lipoprotein oxidative adjustments. Research have proven that PG-ellagitannins are helpful in reducing hyperlipidemia, elevating plasma high-density lipoprotein ldl cholesterol (HDL-C), and bettering complete ldl cholesterol (TC)/HDL-C and low-density lipoprotein ldl cholesterol (LDL-C). /HDL-C ratios. Since weight problems is reversible, dietary interventions can restore metabolic steadiness and stop the event of obesity-related illnesses.

In C57Bl/J6 mice, dietary therapy with pomegranate seed oil diminished fats mass and physique weight whereas enhancing insulin sensitivity in peripheral tissues. These outcomes help earlier findings that indicated a big discount in lipid parameters, together with plasma TC focus, triglyceride content material, and complete ldl cholesterol/high-density lipoprotein ratio. Enzymes related to lipid metabolism, resembling carnitine palmitoyl transferase-1 (CPT 1) and acyl-CoA oxidase (AOX), and nuclear receptors resembling peroxisome proliferator-activated receptor alpha (PPAR-α) positively have an effect on floral PG parts.

Research have reported weight reduction after taking PG extracts for 30 days. Nonetheless, conflicting outcomes have been documented concerning meals consumption and weight achieve. The reported discrepancies could also be defined by variable physiological responses to phytochemicals ensuing from genetic variations.

Conventional medication research PG polyphenols for his or her anti-diabetic properties. PG could exert its results through a wide range of mechanisms, together with modulation of PPAR-γ exercise, resistance to protein degradation, adiponectin gene expression, and inhibition of β-glucosidase, glucose transporter protein kind 4 (Glut-4) and ribonucleic acid (mRNA) enzymatic actions. . ) expression, and regeneration of β mass.

Brief-term therapy with PG peel extract can scale back alpha-amylase exercise, blood glucose ranges, and lipid peroxidation. Research have indicated that PG consumption can enhance plasma HDL-C concentrations in hyperlipidemia sufferers and management lipid parameters in dyslipidemia people with kind 2 diabetes.

Pharmacokinetics, pharmacodynamics, and security of ellagitannin parts in PG compounds

Punicic acid, a PG compound, has been discovered to have potential well being advantages. A number of components, together with the physicochemical properties of molecules and particular person components, together with microbiota composition and intestinal pH, regulate the bioavailability and absorption capabilities of a compound. The flexibility to provide and take up urolithins varies extensively, with punicalagin being detected at a most focus (C-max) of 30 g/mL in rats fed a food regimen containing six % punicalagin.

Within the physique’s tissues, urolithin accumulates within the colon and prostate, with restricted capability to achieve organs such because the liver and kidneys. The biochemical properties of organ cells, resembling their selectivity and permeability properties, the general construction of the ellagitannin (ET) molecule, and particular person variations in transfusion effectivity could all affect the dispersion and sedimentation capabilities of PG ellagitannins.

Though conventional medication literature helps using PG and its capability to enhance well being outcomes, a number of toxicity research have revealed modification of mobile parts and nuclear harm after PG ingestion.

within the laboratory And Alive Toxicological research of PG seed oil, a excessive supply of punicic acid, have discovered that it’s neither mutagenic nor carcinogenic. Submit-mortem examinations revealed no mobile abnormalities, and ingestion of 4.3 g/kg/day of PG resulted in no hurt. The usage of PG or pure PG compounds seems secure, with opposed results anticipated at doses a lot larger than these seen in conventional ethnomedicine therapies that are actually used for therapeutic functions.


General, the evaluate outcomes confirmed that PG consumption could assist stop metabolic issues resembling hyperglycemia and hyperlipidemia; Nonetheless, medical and pharmacokinetic research are inconsistent because of components resembling choice of plant elements, cultivar, geographic area, bioclimatic and soil traits, plasma bioavailability, organ accessibility, and dietary genetics concerns. No matter these variations, the medical efficacy of PG in treating parts of the metabolic syndrome requires multifaceted therapeutic approaches.

Journal reference:

  • Al-Alami, M.; Bomzog, Okay.; Khalil, A.; Ramson, M.; Bulparod, S.; Fulop, T.; Morfaridzadeh, M.; Berrougui, H. Biomodulatory results of pomegranate (Punica granatum L.) polyphenols on metabolic issues: understanding their protecting position towards metabolic syndrome, Vitamins2023, 15, 4879. Bang:

    (Tags for translation) Blood 

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