A brand new examine means that dietary saturated fats could have an effect on male hormone ranges

In a latest examine printed in European Journal of Scientific Dietresearchers studied the connection between dietary fatty acid consumption and serum steroid hormone binding globulin (SHBG) and testosterone ranges in a middle-aged male inhabitants in japanese Finland.

Study: Dietary fat quality and blood androgen concentrations in middle-aged men.  Image credit: Val Lawless/ShutterstockResearch: Dietary fats high quality and blood androgen concentrations in middle-aged males. Picture credit score: Val Lawless/Shutterstock


Blood ranges of testosterone in males have declined in latest a long time, and the explanations for this are unclear. Low testosterone ranges are related to weight problems, impotence, metabolic syndrome, and sort 2 diabetes. Due to this fact, regular testosterone ranges are essential to male well being. Age, physique mass index, alcohol consumption, bodily exercise, and smoking standing have an effect on testosterone ranges.

Research have indicated that modifications within the high quality of dietary fats might also have an effect on blood testosterone ranges. Particularly, elevated consumption of polyunsaturated fatty acids (PUFA) has been linked to decrease serum testosterone. Though research have investigated the connection between the kind of dietary fats consumption, i.e. PUFA, monounsaturated fatty acids (MUFA), and saturated fatty acids (SFA) consumption, and androgen ranges, outcomes are contradictory. Extra analysis may inform dietary methods and interventions to enhance male reproductive well being.

Concerning the examine

On this cross-sectional examine, researchers explored the impact of particular person dietary fatty acid consumption on androgen ranges in middle-aged males.

The examine inhabitants included 2,546 males (imply age 53 years) who participated within the Kuopio Ischemic Coronary heart Illness (KIHD) Threat Elements Research. Knowledge had been obtained on the KIHD baseline examinations between 1984 and 1989 from 2682 males aged 42 years, 48 ​​years, 54 years, or 60 years at examine entry and residing within the metropolis of Kuopio or surrounding communities.

The group excluded 59 topics with lacking information on serum androgen ranges, 26 topics with inadequate information on dietary consumption, 50 most cancers sufferers, and one particular person receiving hormone remedy. Blood samples had been obtained from all individuals. Academic attainment and family revenue had been assessed utilizing self-administered questionnaires.

The annual KIHD Leisure-Time Bodily Exercise Questionnaire was used to find out bodily exercise ranges. SHBG and testosterone concentrations had been decided utilizing time-resolved fluorescent immunoassay. Dietary consumption was assessed at baseline utilizing dietary data for 4 days, together with one weekend and three weekdays.

Linear regression modeling was carried out to find out the relationships between dietary consumption of MUFA, PUFA, SFA, trans fatty acids (TFA) and serum SHBG and free and whole testosterone ranges. As well as, multivariate nutrient density modeling was carried out to find out the connection between isocaloric nutrient replacements and androgen ranges.


After adjusting for age, caloric consumption, and 12 months of examination, amongst 2546 male topics, elevated SFA consumption was related to increased serum SHBG concentrations, free and whole testosterone ranges, and elevated PUFA consumption at decrease ranges. Nonetheless, the relationships weakened and have become nonsignificant after adjusting for different doubtlessly confounding components. TFA and MUFA consumption was not related to androgen ranges.

In isocaloric substitute fashions, changing dietary protein with saturated fatty acids was related to increased serum SHBG and whole testosterone ranges. Particularly, changing energy from protein with these from SFA was related to 1.0 nmol/L increased ranges of SHBG and 0.3 nmol/L increased whole serum testosterone. Related associations had been obtained utilizing energy-adjusted fatty acid consumption in grams per day. Excluding 1021 males with a previous historical past of diabetes or heart problems, there have been no vital associations. Multivariate-adjusted isocaloric substitute evaluation confirmed that changing energy obtained from proteins with these obtained from saturated fatty acids elevated SHBG ranges by 0.7 nmol/L and testosterone concentrations by 0.1 nmol/L.

People with elevated SFA consumption had higher consumption of MUFA and decrease consumption of PUFA, greens, fruits, and berries. Excessive SFA consumption was additionally related to decrease academic attainment and bodily exercise. Elevated PUFA consumption was related to decrease saturated fats consumption, much less cigarette smoking, higher consumption of MUFA, greens, berries, and fruits, increased academic attainment, and extra bodily exercise. People with elevated MUFA consumption had elevated PUFA and SFA consumption, decreased consumption of greens, fiber, fruits, and berries, and had been much less bodily lively.

General, the examine outcomes confirmed no unbiased associations between dietary fats and serum androgen concentrations amongst middle-aged males. Nonetheless, changing energy from proteins with saturated fatty acids could increase serum androgen ranges. Additional research are wanted to find out causal associations between dietary fats consumption and serum androgen concentrations. Future research, corresponding to randomized managed trials, may embrace various populations to enhance the generalizability of examine outcomes. Properly-controlled research with observational designs that have in mind dietary alternate options can yield precious insights.

    (Tags for translation) Hormone 

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